9/1/2023 0 Comments Statins and grapefruit cyp3a4![]() ![]() Corticosteroids: fluticasone propionate.Cholesterol-lowering drugs (statins): simvastatin, atorvastatin, and lovastatin.Anticancer drugs: endoxifen, tamoxifen, and sunitinib.Antihypertensive drugs: felodipine and nifedipine.Immunosuppressants: cyclosporine, tacrolimus, and sirolimus. ![]() This enzyme is one of the most important CYP enzymes since it is responsible for processing approximately 45–60% of prescribed drugs : Find out more about its function, gene variants, and factors that decrease/increase CYP3A4 activity.ĬYP3A4 is one of the cytochrome P450 monooxygenases (CYPs), which are enzymes that eliminate most of the drugs and toxins from our body. Different supplements, food components, and drugs can change CYP3A4 activity and, as a result, interfere with drug metabolism. A plus sign next to the number “” means that the information is found within the full scientific study rather than the abstract.ĬYP3A4 is an important CYP enzyme, responsible for clearing approximately 45 – 60% of currently prescribed drugs. Note that each number in parentheses is a clickable link to peer-reviewed scientific studies. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at. Our goal is to not have a single piece of inaccurate information on this website. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists.Īll of our content is written by scientists and people with a strong science background. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. We believe that the most accurate information is found directly in the scientific source. SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. ![]()
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